Single-particle Cryo-EM of Biological Macromolecules

This is an edited book that provides a comprehensive, accessible and authoritative introduction to the field of high-resolution structure analysis by single-particle cryo-EM. It covers all necessary background, ranging from the underlying concepts to practical aspects such as specimen preparation, data-collection, data analysis, and the final validation of results.


About the Author
Glaeser, Robert M.: - Professor Glaeser (UC Berkeley) made major contributions to the initial development of cryo-EM technology, and he currently is active in the improvement of specimen preparation.Nogales, Eva: - Professor Nogales (UC Berkeley) has used cryo-EM throughout her scientific career, successfully applying this technique for the last three decades that defied structural characterization.Chiu, Wah: - Professor Chiu (Stanford University) developed early experimental and computational methods towards 3D structure determination of biomolecules towards 3D atomic resolution: contributed to the establishment of validation methods to assess cryoEM structures.