Development of Isatin as CNS Agents: Anticonvulsant activity - Paperback
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Languages:EnglishPublisher:Anchor Academic PublishingISBN-13:9783954892792ISBN-10:3954892790UPC:9783954892792Book Category:ScienceBook Subcategory:Life SciencesBook Topic:BiologySize:8.27 x 5.83 x 0.13 inchesWeight:0.086Product ID:SCP39HECXW
The present study was aimed at synthesizing isatin-5-sulphonamide derivatives are prepared by chlorosulphonation of isatin to prepare isatin-5-sulphonic acid chloride and it is subjected to reaction with different amines or anilines to form respective sulphonamide derivatives. The new compounds were characterized based on spectral (FT-IR, NMR and Mass) analysis. All the test compounds showed CNS depression while studying the gross behavioral changes. All the test compounds exhibited reduction in locomotor activity. Compound IIIf (R = p-toluidino) showed more reduction in the locomotor activity among all the test compounds. Compounds IIId, IIIc, IIIb, IIIa were next in the order of reduction of locomotor activity. The compounds were evaluated for anticonvulsant activity against maximum electric shock induced and Pentylenetetrazol (PTZ) induced seizures in mice using phenytoin as a standard.
Languages:EnglishPublisher:Anchor Academic PublishingISBN-13:9783954892792ISBN-10:3954892790UPC:9783954892792Book Category:ScienceBook Subcategory:Life SciencesBook Topic:BiologySize:8.27 x 5.83 x 0.13 inchesWeight:0.086Product ID:SCP39HECXW
Gangarapu Kiran, M.Pharm, (Ph.D) is Assistant Professor of Kakatiya Institute of Pharmaceutical Sciences, Pembarthy, Warangal. He has an experience of about 7 years in teaching medicinal chemistry and performing research work in synthetic medicinal chemistry and pharmaceutical analysis. He submitted his Ph.D from Jawaharlal Nehru Technological University Hyderabad. He has published about 30 research papers in national and international journals. His research activities are collaborated with various research organizations like Rega Institute for Medical Research, Belgium; Graduate School of Medical Science Kanazawa University, Japan and National Cancer Institute, USA.
Publisher: Anchor Academic Publishing
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