Physiological Mapping of the Cerebral Cortex in Neuropathology: Mitochondrial Function, Cbf, Ionic Homeostasis and Electrical Activities - Hardcover
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This book covers a new concept and unique approach named "Physiological Mapping" of the cerebral cortex in the rat's brain. The unique parameter that is used in the authors' studies is the monitoring, in vivo and in real time, of the mitochondrial NADH redox state. In addition, the monitoring of cerebral blood flow, tissue oxygen level, extracellular potassium ion and DC potential as well as ECoG is reported.
The main pathological event that was studied was cerebral ischemia that mimic the stroke developed in patients. Different models of ischemia were investigated by using the developed concept of "Physiological Mapping". A unique chapter in the book describes and discuss an event named "Metabolic Oscillations" that developed mainly in the ischemic brain. Also the role of nitric oxide in various pathophysiological conditions such as ischemia, hypoxia, and hypercapnia are discussed.
In addition to stroke, the book describes in detail the physiological mapping of the cerebral cortex in the brain exposed to epilepsy. The interaction between the epilepsy developed in the brain and partial ischemia, nitric oxide, hyperoxia and anesthesia is presented in detail.
The last chapter of the book describes the effects of an animal's age on the responses to ischemia. Also the effects of traumatic brain injury in the rat is discussed.
This is an ideal book for neurologists as well as clinicians in the field of neurosurgery and anesthesiology.
Prof. Avraham Mayevsky is a Professor Emeritus in The Mina & Everard Goodman Faculty of Life Sciences and the Leslie and Susan Gonda Multidisciplinary Brain Research Center at Bar-Ilan University in Ramat-Gan, Israel.
Prof. Avraham Mayevsky's field of research since he started his Post-Doc training with Prof. Britton Chance in 1972, was Energy metabolism, including mitochondrial function in vivo, of the brain mainly and other tissues In Vivo, exposed to various pathophysiological conditions. During the 50 years of activity he was able to accomplish a large number of goals that have a very significant impact on the understanding of pathophysiological processes in the brain and other organs evaluated under In Vivo conditions. His vision was to develop experimental approaches and tools that will enable him to study various physiological processes in experimental animals and at the same time, will be ready for clinical applications.
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