Metronidazole Extended Release Solid Dosage Form - Paperback

Metronidazole Extended Release Solid Dosage Form

This pharmaceutical reference provides detailed information on metronidazole extended release formulations designed to optimize therapeutic outcomes while minimizing adverse effects. The text addresses critical challenges in metronidazole administration and presents extended release technology as a solution for improved patient compliance and sustained therapeutic plasma levels.

Clinical Administration Challenges

Currently two effective ways are used with the administration of a metronidazole composition. A single, large dose is given as a bolus to the patient which is clinically effective but a major drawback to the administration of single large dose of metronidazole is the occurrence of significant and undesirable side effects. A second and more generally accepted treatment entails orally administering smaller dose of metronidazole three time a day. The lower dosage of metronidazole over a period of a week significantly reduces the occurrence and severity of side effect but patient compliance is a problem can inadvertently forget to take one or more doses during the course of treatment, causing the plasma metronidazole level drop to bellow an acceptable therapeutic level for a period of several hours or more.

Extended Release Formulation Benefits

Extended release formulation of metronidazole could be suitable alternative for reducing the number of daily doses needed to treat a microbial infection, while maintaining the benefit of making bioavailable effective amount of drug over an extended time period. This formulation strategy addresses both the side effect profile associated with bolus dosing and the compliance issues inherent in multiple daily dosing regimens.

Target Audience

This resource is intended for healthcare professionals, pharmaceutical scientists, clinical pharmacologists, and medical education professionals seeking in-depth understanding of metronidazole extended release technology. The content covers drug delivery systems, dosage form design, and therapeutic optimization strategies relevant to antimicrobial treatment protocols.

Publication Details

Published by LAP Lambert Academic Publishing in March 2013, this paperback reference is authored by Al-Mamun MD Abdullah and Sukalyan Kumar Kundu. The text serves as both an academic resource and professional development tool for those working in pharmaceutical sciences and clinical pharmacology.